Journal Article Annotations
2020, 3rd Quarter
Annotations by Timothy King, MD
PUBLICATION #1 — Cardiac Psychiatry
This retrospective cohort study adds to the limited existing literature about the increased risk of gastrointestinal bleeds with SSRIs and SNRIs on LVAD patients
Strength and weaknesses:
This larger multi-institutional study confirms previous research about the increase in risk of GI bleeds among LVAD patients on an SSRI or SNRI. Nevertheless, numbers in this study are still relatively small (n=248).
Because LVAD patients are usually at a higher risk of GI bleeds due to antithrombotic therapy, a careful discussion of risks and benefits should be had prior to starting this patient group on SSRI/SNRI therapy. This discussion should emphasize the possible increase risk of GI bleeds: NNH 7.6 in LVAD patients vs NNH 3,177 in the general population using an SSRI in prior studies.
Type of study (EBM guide):