Journal Article Annotations
2023, 2nd Quarter


Annotations by Julian J. Raffoul, MD, PhD
July, 2023

  1. Impact of Medication-Based Treatment on Health Care Utilization Among Individuals with Opioid Use Disorder

PUBLICATION #1 — Addiction

Impact of Medication-Based Treatment on Health Care Utilization Among Individuals with Opioid Use Disorder
Manesh Gopaldas, Kevin Wenzel, Aimee N C Campbell, Ali Jalali, Marc Fishman, John Rotrosen, Edward V Nunes, Sean M Murphy


The finding:
The opioid crisis continues: overdose deaths are at an all-time high and complications of opioid use, including injection drug use, contribute to increased visits to the emergency department and hospitalization. Medication for opioid use disorder (MOUD) is known to improve patient health outcomes. The findings published by this secondary analysis of data from the National Institute on Drug Abuse comparative effectiveness trial known as X:BOT, a 24-week randomized controlled trial comparing the effectiveness of treatment with extended-release naltrexone (XR-NTX) versus sublingual buprenorphine-naloxone (BUP-NX), demonstrated that patients with high adherence (≥ 80% of days taking MOUD) compared with low adherence (< 20%) to MOUD were significantly less likely to use both high-cost inpatient and acute care services and were significantly more likely to engage in outpatient care. Interventions that increase MOUD uptake and adherence may reduce health care costs.

Strength and weaknesses:
A  novel methodological approach was used in this study to examine the association between adherence to MOUD and health care utilization over time among participants  allowed for more precise measures of MOUD adherence and health care utilization over time, as well as an extensive list of individual and social determinants of health, measured at the participant level. Additional strengths included the relatively large community-based sample (XR-NTX N=283 versus BUP-NX N=287) and the use of repeated-measures analysis with time-dependent adherence. Limitations of the study include self-reported data regarding adherence and service utilization and as a secondary analysis, this study was not part of the parent study’s a priori design. Lastly, non-adherence and deterioration of adherence over time was observed in this study. Causation cannot be inferred from the data, but the data suggested that interventions that increase MOUD uptake and adherence can reduce healthcare costs.

MOUD are known to be an effective treatment for patients with an OUD and are associated with both decreased morbidity and mortality. Research has also consistently shown that a major gap exists between the number of patients in need of treatment for OUD and the number of physicians available or willing to prescribe treatment. This study highlights the important role that C-L psychiatrists may play when consulted on patients who present to the emergency department or require hospitalization due to an OUD. Recommending the use of MOUD for these patients will help save lives and reduce the strain on an already burdened health care system.